The Hotel Giotto Assisi is 200 meters from the Basilica of Saint Francis. The Hotel Giotto Assisi is about 10 minutes from the train station and 30 minutes from the airport.

There are 70 rooms at the Hotel Giotto Assisi, one of which is a suite. Rooms have their own balconies, which provide views down over the valley to Spoleto. Other features include free wireless Internet access, minibar, satellite television, direct dial phone, and en suite bathroom.

The Hotel Giotto Assisi is a restored building originally built in 1900. There is a full service restaurant on site that offers locally sourced Umbrian specialties and has a designated non-smoking area. The morning breakfast buffet is complimentary for guests. Light business services are offered at the lobby area information desk. There is a conference room that can accommodate up to 80 people. The bar offers evening cocktails and coffees. For relaxation, the hotel offers an excursions program, or guests can lounge by the outdoor swimming pool in season.